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    rde-3 PAP-associated domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rde-3
    Official Full Name
    PAP-associated domain-containing protein
    Primary source
    WormBase:WBGene00003499
    Locus tag
    CELE_K04F10.6
    See related
    AllianceGenome:WB:WBGene00003499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Involved in embryo development; meiotic chromosome segregation; and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in mutator focus. Is expressed in germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rde-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (6356614..6358410, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Endoprotease bli-4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Vacuolar protein sorting-associated protein 28 homolog Neighboring gene Protein KATNIP homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Removing bias against short sequences enables northern blotting to better complement RNA-seq for the study of small RNAs. Choi YS, et al. Nucleic Acids Res, 2017 Jun 2. PMID 28180294, Free PMC Article
    2. poly(UG)-tailed RNAs in genome protection and epigenetic inheritance. Shukla A, et al. Nature, 2020 Jun. PMID 32499657, Free PMC Article
    3. The Tc1/mariner transposon family. Plasterk RH. Curr Top Microbiol Immunol, 1996. PMID 8556864
    4. A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans. Chen CC, et al. Curr Biol, 2005 Feb 22. PMID 15723801
    5. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Ahmed S, et al. Nature, 2000 Jan 13. PMID 10646593

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rde-3 is required for siRNA accumulation and for efficient RNAi in all tissues, and it is essential for fertility and viability at high temperatures.
      Title: A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    PAP-associated domain-containing protein
    NP_491834.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6356614..6358410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059433.8 → NP_491834.1  PAP-associated domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491834.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44768
      Conserved Domains (1) summary
      COG5260
      Location:74 → 376
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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