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    rom-1 Rhomboid-related protein 1 [ Caenorhabditis elegans ]

    Gene ID: 184989, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rom-1
    Official Full Name
    Rhomboid-related protein 1
    Primary source
    WormBase:WBGene00004400
    Locus tag
    CELE_F26F4.3
    See related
    AllianceGenome:WB:WBGene00004400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in positive regulation of vulval development. Predicted to be located in membrane. Is expressed in several structures, including head; intestine; pharyngeal-intestinal valve; rectal gland cell; and vulval muscle. Orthologous to several human genes including RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rom-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (4907196..4908993)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene START domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 21 Neighboring gene C2H2-type domain-containing protein Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene DUF3149 domain-containing protein;Glutaredoxin domain-containing protein Neighboring gene PDZ domain-containing protein Neighboring gene Conserved Edge Expressed protein Neighboring gene arginine--tRNA ligase;putative arginine--tRNA ligase, cytoplasmic

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Karyotype, ploidy, and gene dosage. Hodgkin J. WormBook, 2005 Jun 25. PMID 18023124, Free PMC Article
    2. EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid. Dutt A, et al. PLoS Biol, 2004 Nov. PMID 15455032, Free PMC Article
    3. RTK/Ras/MAPK signaling. Sundaram MV. WormBook, 2006 Feb 11. PMID 18050474, Free PMC Article
    4. Vulval development. Sternberg PW. WormBook, 2005 Jun 25. PMID 18050418, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ROM-1 acts as a positive regulator of the EGFR/RAS/MAPK signaling pathway during vulval induction.
      Title: EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.
    2. ROM-1 and ROM-2 play a conserved role in activating EGFR signaling in C. elegans
      Title: EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rhomboid-related protein 1
    NP_498029.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4907196..4908993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065628.4 → NP_498029.2  Rhomboid-related protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498029.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19821
      Conserved Domains (1) summary
      pfam01694
      Location:160 → 308
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19821.2

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