daf-16 Forkhead box protein O [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: daf-16
Official Full Name: Forkhead box protein O
Primary source: WormBase:WBGene00000912
Locus tag: CELE_R13H8.1
See related: AllianceGenome:WB:WBGene00000912
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables several functions, including 14-3-3 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including defense response to other organism; regulation of dauer larval development; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in several structures, including germ cell; germ line; gonad; hypodermis; and neurons. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to several human genes including FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See daf-16 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 15

Sequence:: Chromosome: I; NC_003279.8 (10750498..10776703)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells.
Title: DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells.
Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation.
Title: Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation.
Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing.
Title: Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing.
Jujubae Fructus extract prolongs lifespan and improves stress tolerance in Caenorhabditis elegans dependent on DAF-16/SOD-3.
Title: Jujubae Fructus extract prolongs lifespan and improves stress tolerance in Caenorhabditis elegans dependent on DAF-16/SOD-3.
DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16.
Title: DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16.
Knockdown of phosphatases of regenerating liver-1 prolongs the lifespan of Caenorhabditis elegans via activating DAF-16/FOXO.
Title: Knockdown of phosphatases of regenerating liver-1 prolongs the lifespan of Caenorhabditis elegans via activating DAF-16/FOXO.
DAF-16 is involved in colonic metabolites of ferulic acid-promoted longevity and stress resistance of Caenorhabditis elegans.
Title: DAF-16 is involved in colonic metabolites of ferulic acid-promoted longevity and stress resistance of Caenorhabditis elegans.
The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan.
Title: The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan.
Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections.
Title: Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections.
Regulation of DAF-16-mediated longevity and immune response to Candida albicans infection in Caenorhabditis elegans.
Title: Regulation of DAF-16-mediated longevity and immune response to Candida albicans infection in Caenorhabditis elegans.

Submit: New GeneRIF Correction See all GeneRIFs (163)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13H8.2 (e-PCR)
- UniSTS:320125

R13H8.1 (e-PCR)
- UniSTS:307111

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables DEAD/H-box RNA helicase binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-specific protease binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heat acclimation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle process	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in response to UV	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sleep	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Forkhead box protein O

NP_001021593.1

Confirmed by transcript evidence

NP_001021596.1

Confirmed by transcript evidence

NP_001021598.2

Confirmed by transcript evidence

NP_001364784.1

Confirmed by transcript evidence

NP_001364785.1

Confirmed by transcript evidence

NP_001367892.1

Confirmed by transcript evidence

NP_001367893.1

Confirmed by transcript evidence

NP_001368498.1

Confirmed by transcript evidence

NP_001368499.1

Confirmed by transcript evidence

NP_001368501.1

Confirmed by transcript evidence

NP_001368502.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10750498..10776703

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381205.1 → NP_001367893.1 Forkhead box protein O [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

F3NWW7, F3NWX0, G4RQR7, G4S686, G4SKG3, G4SKH0, O16849, O16850, O18676, Q86S42

Conserved Domains (1) summary

cd20032
Location:176 → 255

FH_FOXO; Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily
NM_001026427.7 → NP_001021598.2 Forkhead box protein O [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021598.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O16850

Conserved Domains (1) summary

cd00059
Location:151 → 231

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_001381206.1 → NP_001368498.1 Forkhead box protein O [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWG6

Conserved Domains (1) summary

cd20032
Location:150 → 229

FH_FOXO; Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily
NM_001026425.6 → NP_001021596.1 Forkhead box protein O [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021596.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16850

Conserved Domains (1) summary

cd00059
Location:121 → 201

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_001381207.1 → NP_001368499.1 Forkhead box protein O [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AR63

Conserved Domains (1) summary

cd20032
Location:120 → 199

FH_FOXO; Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily
NM_001377627.2 → NP_001364785.1 Forkhead box protein O [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd20032
Location:145 → 224

FH_FOXO; Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily
NM_001377628.3 → NP_001364784.1 Forkhead box protein O [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

COG5025
Location:60 → 224

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd20032
Location:143 → 222

FH_FOXO; Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily
NM_001381208.1 → NP_001368501.1 Forkhead box protein O [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AR95

Conserved Domains (1) summary

cd20032
Location:42 → 121

FH_FOXO; Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily
NM_001381209.1 → NP_001368502.1 Forkhead box protein O [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ATP5

Conserved Domains (1) summary

cd20032
Location:40 → 119

FH_FOXO; Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily
NM_001026422.6 → NP_001021593.1 Forkhead box protein O [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021593.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16850

Conserved Domains (1) summary

smart00339
Location:164 → 249

FH; FORKHEAD
NM_001381210.1 → NP_001367892.1 Forkhead box protein O [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl00061
Location:1 → 19

FH_FOX; Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins