U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ckk-1 Calcium/calmodulin-dependent protein kinase kinase [ Caenorhabditis elegans ]

    Gene ID: 182278, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ckk-1
    Official Full Name
    Calcium/calmodulin-dependent protein kinase kinase
    Primary source
    WormBase:WBGene00000518
    Locus tag
    CELE_C05H8.1
    See related
    AllianceGenome:WB:WBGene00000518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in CAMKK-AMPK signaling cascade. Located in cytoplasm and nucleus. Is expressed in head neurons; tail neurons; and vulval muscle. Orthologous to several human genes including CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ckk-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (5635479..5654564)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ca(2+)/Calmodulin-dependent protein kinase cascade in Caenorhabditis elegans. Implication in transcriptional activation. Eto K, et al. J Biol Chem, 1999 Aug 6. PMID 10428833
    2. Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in a C. elegans thermal nociceptor. Ippolito D, et al. Elife, 2023 May 11. PMID 37166173, Free PMC Article
    3. 5'-AMP-activated protein kinase signaling in Caenorhabditis elegans. Beale EG. Exp Biol Med (Maywood), 2008 Jan. PMID 18156301
    4. Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain. Tokumitsu H, et al. J Biol Chem, 1999 May 28. PMID 10336483
    5. A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. Kimura Y, et al. EMBO Rep, 2002 Oct. PMID 12231504, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAMKK-AMPK signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Calcium/calmodulin-dependent protein kinase kinase
    NP_001021152.1
    • Confirmed by transcript evidence
    NP_001021153.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5635479..5654564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025982.5 → NP_001021153.1  Calcium/calmodulin-dependent protein kinase kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4RS26, G5EDZ4, Q3Y416
      Conserved Domains (2) summary
      smart00220
      Location:130 → 411
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14118
      Location:135 → 412
      STKc_CAMKK; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase

    2. NM_001025981.3 → NP_001021152.1  Calcium/calmodulin-dependent protein kinase kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021152.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3Y416
      Conserved Domains (2) summary
      smart00220
      Location:21 → 302
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14118
      Location:26 → 303
      STKc_CAMKK; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3Y416.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.