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    trim-21 E3 ubiquitin-protein ligase trim-21 [ Caenorhabditis elegans ]

    Gene ID: 181901, updated on 4-Jan-2025

    Summary

    Official Symbol
    trim-21
    Official Full Name
    E3 ubiquitin-protein ligase trim-21
    Primary source
    WormBase:WBGene00015114
    Locus tag
    CELE_B0281.8
    See related
    AllianceGenome:WB:WBGene00015114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Is expressed widely. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to several human genes including BSPRY (B-box and SPRY domain containing); MEFV (MEFV innate immunity regulator, pyrin); and RNF39 (ring finger protein 39). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See trim-21 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (2311490..2312892, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene pseudo

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase trim-21
    NP_001408271.1
    • Partially confirmed by transcript evidence
    NP_001408272.1
    • Partially confirmed by transcript evidence
    NP_001408273.1
    • Partially confirmed by transcript evidence
    NP_494234.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2311490..2312892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001421344.1NP_001408273.1  E3 ubiquitin-protein ligase trim-21 [Caenorhabditis elegans]

      Status: REVIEWED

    2. NM_001421345.1NP_001408272.1  E3 ubiquitin-protein ligase trim-21 [Caenorhabditis elegans]

      Status: REVIEWED

    3. NM_001421346.1NP_001408271.1  E3 ubiquitin-protein ligase trim-21 [Caenorhabditis elegans]

      Status: REVIEWED

    4. NM_061833.1NP_494234.1  E3 ubiquitin-protein ligase trim-21 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494234.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16616
      Conserved Domains (4) summary
      PRK00409
      Location:135249
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      cd00162
      Location:651
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19774
      Location:91137
      Bbox2_TRIM23_C-IX_rpt2; second B-box-type 2 zinc finger found in tripartite motif-containing protein 23 (TRIM23) and similar proteins
      cl17238
      Location:652
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain