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    ZC196.2 Major sperm protein [ Caenorhabditis elegans ]

    Gene ID: 191101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZC196.2
    Official Full Name
    Major sperm protein
    Primary source
    WormBase:WBGene00022546
    Locus tag
    CELE_ZC196.2
    See related
    AllianceGenome:WB:WBGene00022546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-membrane adaptor activity. Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum-plasma membrane tethering. Predicted to be located in cytoskeleton. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPA (VAMP associated protein A) and VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZC196.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (8739436..8742311)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Death domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene ULP_PROTEASE domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum-plasma membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Major sperm protein
    NP_505251.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8739436..8742311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072850.4 → NP_505251.2  Major sperm protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505251.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01630
      Conserved Domains (1) summary
      pfam00635
      Location:7 → 112
      Motile_Sperm; MSP (Major sperm protein) domain
    Nucleotide Protein
    Heading Accession and Version

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