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    dyf-3 Clusterin-associated protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 177107, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dyf-3
    Official Full Name
    Clusterin-associated protein 1 homolog
    Primary source
    WormBase:WBGene00001119
    Locus tag
    CELE_C04C3.5
    See related
    AllianceGenome:WB:WBGene00001119
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including chemosensory behavior; cilium assembly; and response to alkaline pH. Located in axon; dendrite; and neuronal cell body. Is expressed in nervous system. Orthologous to human CLUAP1 (clusterin associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dyf-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (3396581..3399231, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Neighboring gene Neurotransmitter-gated ion-channel ligand binding domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans. Murayama T, et al. J Mol Biol, 2005 Feb 25. PMID 15713455
    2. The PKD protein qilin undergoes intraflagellar transport. Ou G, et al. Curr Biol, 2005 Jun 7. PMID 15936258
    3. Functional genomics of intraflagellar transport-associated proteins in C. elegans. Inglis PN, et al. Methods Cell Biol, 2009. PMID 20409822
    4. Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans. Murayama T, et al. Curr Biol, 2013 Jun 3. PMID 23664973
    5. Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia. Yi P, et al. Curr Biol, 2017 May 22. PMID 28479320

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Clusterin-associated protein 1 homolog
    NP_001021296.1
    • Confirmed by transcript evidence
    NP_001367377.1
    • Confirmed by transcript evidence
    NP_001367378.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3396581..3399231 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380145.1 → NP_001367377.1  Clusterin-associated protein 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam10234
      Location:1 → 208
      Cluap1; Clusterin-associated protein-1

    2. NM_001380144.1 → NP_001367378.1  Clusterin-associated protein 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEH8, Q6I6D4, Q6I6D5
      Conserved Domains (1) summary
      pfam10234
      Location:14 → 281
      Cluap1; Clusterin-associated protein-1

    3. NM_001026125.3 → NP_001021296.1  Clusterin-associated protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021296.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6I6D4
      Conserved Domains (2) summary
      pfam10234
      Location:8 → 266
      Cluap1; Clusterin-associated protein-1
      cl19764
      Location:164 → 270
      COG6; Conserved oligomeric complex COG6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6I6D4.2

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