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    mys-4 histone acetyltransferase [ Caenorhabditis elegans ]

    Gene ID: 183194, updated on 27-Dec-2024

    Summary

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    Official Symbol
    mys-4
    Official Full Name
    histone acetyltransferase
    Primary source
    WormBase:WBGene00007914
    Locus tag
    CELE_C34B7.4
    See related
    AllianceGenome:WB:WBGene00007914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity; histone acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of histone H3-K14 acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mys-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (8333082..8336727)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein uL23B Neighboring gene UPAR/Ly6 domain-containing protein Neighboring gene SAC domain-containing protein Neighboring gene putative cytochrome P450 CYP36A1 Neighboring gene Tubulin alpha chain Neighboring gene Tudor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans. Shibata Y, et al. Development, 2010 Apr. PMID 20181741
    2. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Ceol CJ, et al. Dev Cell, 2004 Apr. PMID 15068795
    3. Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. Cui M, et al. PLoS Genet, 2006 May. PMID 16710447, Free PMC Article
    4. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Wang S, et al. Nat Struct Mol Biol, 2020 Dec. PMID 33046905
    5. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone H3-K14 acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase
    NP_492265.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8333082..8336727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059864.4 → NP_492265.1  histone acetyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95ZX6
      Conserved Domains (4) summary
      PLN00058
      Location:35 → 117
      PLN00058; photosystem II reaction center subunit T; Provisional
      smart00249
      Location:147 → 193
      PHD; PHD zinc finger
      pfam01853
      Location:391 → 565
      MOZ_SAS; MOZ/SAS family
      cl17182
      Location:347 → 603
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version

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