sas-4 Spindle assembly abnormal protein 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sas-4
Official Full Name: Spindle assembly abnormal protein 4
Primary source: WormBase:WBGene00004726
Locus tag: CELE_F10E9.8
See related: AllianceGenome:WB:WBGene00004726
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in centriole replication and maintenance of protein location. Located in centriole. Is expressed in gonad; intestinal cell; and sperm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sas-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (8314349..8318588, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Centriolar SAS-4 remains in dynamic equilibrium with the cytoplasmic pool until late prophase, when it is stably incorporated in a step that requires gamma-tubulin and microtubule assembly.
Title: SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.
SAS-4 is recruited to the centrosome once per cell cycle, at the time of organelle duplication; then to the daughter centriole or a closely associated structure. SAS-4 recruitment is a key step in the centrosome duplication cycle.
Title: SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle.
SAS-4 is a centriole-associated component whose amount dictates centrosome size
Title: SAS-4 is a C. elegans centriolar protein that controls centrosome size.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-170 (e-PCR)
- UniSTS:242013

F10E9.8 (e-PCR)
- UniSTS:309661

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Spindle assembly abnormal protein 4

NP_498828.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8314349..8318588 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066427.8 → NP_498828.2 Spindle assembly abnormal protein 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498828.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34402

Conserved Domains (2) summary

pfam10211
Location:394 → 481

Ax_dynein_light; Axonemal dynein light chain

cl19849
Location:439 → 541

DUF881; Bacterial protein of unknown function (DUF881)