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    let-381 Forkhead box protein F [ Caenorhabditis elegans ]

    Gene ID: 172331, updated on 9-Dec-2024

    Summary

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    Official Symbol
    let-381
    Official Full Name
    Forkhead box protein F
    Primary source
    WormBase:WBGene00002601
    Locus tag
    CELE_F26B1.7
    See related
    AllianceGenome:WB:WBGene00002601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables sequence-specific DNA binding activity. Involved in mesodermal cell fate specification; nematode larval development; and positive regulation of mesodermal cell fate specification. Located in nucleus. Is expressed in M.dlp; M.drp; body wall muscle cell from M lineage; and coelomocyte. Human ortholog(s) of this gene implicated in persistent fetal circulation syndrome. Orthologous to several human genes including FOXF1 (forkhead box F1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See let-381 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (6320289..6324019, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class gamma-14 Neighboring gene Importin subunit alpha-2 Neighboring gene Heterogeneous nuclear ribonucleoprotein K homolog Neighboring gene Uncharacterized protein Neighboring gene MS Related Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LET-381/FoxF and its target UNC-30/Pitx2 specify and maintain the molecular identity of C. elegans mesodermal glia that regulate motor behavior. Stefanakis N, et al. EMBO J, 2024 Mar. PMID 38360995, Free PMC Article
    2. A high-content imaging approach to profile C. elegans embryonic development. Wang S, et al. Development, 2019 Apr 11. PMID 30890570, Free PMC Article
    3. The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development. Amin NM, et al. Development, 2010 May. PMID 20335356, Free PMC Article
    4. Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Vavouri T, et al. Cell, 2009 Jul 10. PMID 19596244
    5. The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm. Tian C, et al. Development, 2011 Mar. PMID 21307099, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LET-381/FoxF and its target UNC-30/Pitx2 specify and maintain the molecular identity of C. elegans mesodermal glia that regulate motor behavior.
      Title: LET-381/FoxF and its target UNC-30/Pitx2 specify and maintain the molecular identity of C. elegans mesodermal glia that regulate motor behavior.
    2. Data show that LET-381 functions in a feed-forward mechanism in the specification and differentiation of the non-muscle mesodermal cells, the coelomocytes.
      Title: The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mesodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Forkhead box protein F
    NP_491826.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6320289..6324019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059425.4 → NP_491826.1  Forkhead box protein F [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491826.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91278
      Conserved Domains (1) summary
      cd20020
      Location:73 → 153
      FH_FOXF; Forkhead (FH) domain found in the Forkhead box protein F (FOXF) subfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91278.2

    Gene LinkOut

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