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    Y71H2AM.20 Serine/threonine-protein phosphatase 2A activator [ Caenorhabditis elegans ]

    Gene ID: 175395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y71H2AM.20
    Official Full Name
    Serine/threonine-protein phosphatase 2A activator
    Primary source
    WormBase:WBGene00022185
    Locus tag
    CELE_Y71H2AM.20
    See related
    AllianceGenome:WB:WBGene00022185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity and protein tyrosine phosphatase activator activity. Predicted to be involved in mitotic spindle organization. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y71H2AM.20 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (2782733..2785948, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene HMG box domain-containing protein Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase laf-1 Neighboring gene DNA/pantothenate metabolism flavoprotein C-terminal domain-containing protein;Myotubularin phosphatase domain-containing protein Neighboring gene Cytochrome oxidase c subunit VIb Neighboring gene NADH dehydrogenase [ubiquinone] 1 subunit C2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans. Hammerquist AM, et al. Sci Rep, 2020 Nov 9. PMID 33168938, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein phosphatase 2A activator
    NP_001420388.1
    • Confirmed by transcript evidence
    NP_497617.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2782733..2785948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065216.7 → NP_497617.1  Serine/threonine-protein phosphatase 2A activator [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL35
      Conserved Domains (1) summary
      pfam03095
      Location:9 → 303
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

    2. NM_001433453.1 → NP_001420388.1  Serine/threonine-protein phosphatase 2A activator [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0S3
    Nucleotide Protein
    Heading Accession and Version

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