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    rme-8 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rme-8
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00004378
    Locus tag
    CELE_F18C12.2
    See related
    AllianceGenome:WB:WBGene00004378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Involved in several processes, including mechanosensory behavior; positive regulation of nematode male tail tip morphogenesis; and protein localization to postsynaptic membrane. Located in endosome. Is expressed in coelomocyte; hypodermal cell; muscle cell; oocyte; and uterus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human DNAJC13 (DnaJ heat shock protein family (Hsp40) member C13). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rme-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    23
    Sequence:
    Chromosome: I; NC_003279.8 (8083576..8095610)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small integral membrane protein 29 Neighboring gene Cytoplasmic dynein 2 heavy chain 1 Neighboring gene ncRNA Neighboring gene Serum response factor-binding protein 1 Neighboring gene Suppressor of presenilin protein 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RME-8, a conserved J-domain protein, is required for endocytosis in Caenorhabditis elegans. Zhang Y, et al. Mol Biol Cell, 2001 Jul. PMID 11451999, Free PMC Article
    2. Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis. Besemer AS, et al. Cell Mol Life Sci, 2021 Jan. PMID 32322926, Free PMC Article
    3. The DnaJ-domain protein RME-8 functions in endosomal trafficking. Girard M, et al. J Biol Chem, 2005 Dec 2. PMID 16179350
    4. Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog. Fares H, et al. Nat Genet, 2001 May. PMID 11326278
    5. SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes. Norris A, et al. Proc Natl Acad Sci U S A, 2017 Jan 17. PMID 28053230, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis.
      Title: Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis.
    2. Loss of SNX-1, RME-8, or the clathrin chaperone Hsc70/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 to the lysosome.
      Title: Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    J domain-containing protein
    NP_001021395.1
    • Confirmed by transcript evidence
    NP_492222.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8083576..8095610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026224.6 → NP_001021395.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62178
      Conserved Domains (2) summary
      pfam00226
      Location:1324 → 1378
      DnaJ; DnaJ domain
      pfam14237
      Location:983 → 1033
      DUF4339; Domain of unknown function (DUF4339)

    2. NM_059821.5 → NP_492222.2  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492222.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED36
      Conserved Domains (2) summary
      pfam00226
      Location:1324 → 1378
      DnaJ; DnaJ domain
      pfam14237
      Location:983 → 1033
      DUF4339; Domain of unknown function (DUF4339)
    Nucleotide Protein
    Heading Accession and Version

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