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    ddx-46 ATP-dependent RNA helicase;Pre-mRNA-processing ATP-dependent RNA helicase PRP5;RNA helicase [ Caenorhabditis elegans ]

    Gene ID: 176943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddx-46
    Official Full Name
    ATP-dependent RNA helicase;Pre-mRNA-processing ATP-dependent RNA helicase PRP5;RNA helicase
    Primary source
    WormBase:WBGene00018776
    Locus tag
    CELE_F53H1.1
    See related
    AllianceGenome:WB:WBGene00018776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in P granule. Predicted to be active in nucleus. Orthologous to human DDX46 (DEAD-box helicase 46). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ddx-46 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (1297222..1309650, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene 30S ribosomal protein S15;DNA_pol_B_exo1 domain-containing protein;Transposase;Uncharacterized protein Neighboring gene Calponin-homology (CH) domain-containing protein Neighboring gene PHD-type domain-containing protein Neighboring gene UDENN domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response. Quach TK, et al. PLoS One, 2013. PMID 23533643, Free PMC Article
    2. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
    3. Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Xia Q, et al. Redox Biol, 2023 Apr. PMID 36791646, Free PMC Article
    4. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article
    5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase;Pre-mRNA-processing ATP-dependent RNA helicase PRP5;RNA helicase
    NP_001033411.1
    • Confirmed by transcript evidence
    NP_001294485.1
    • Confirmed by transcript evidence
    NP_001294486.1
    • Confirmed by transcript evidence
    NP_001294487.1
    • Confirmed by transcript evidence
    NP_001368269.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1297222..1309650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038322.5 → NP_001033411.1  ATP-dependent RNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001033411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q965K2
      Conserved Domains (3) summary
      COG0513
      Location:276 → 793
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:534 → 655
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:316 → 514
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    2. NM_001307556.3 → NP_001294485.1  Pre-mRNA-processing ATP-dependent RNA helicase PRP5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294485.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRR4
      Conserved Domains (3) summary
      COG0513
      Location:276 → 744
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:534 → 655
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:316 → 514
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    3. NM_001307558.3 → NP_001294487.1  Pre-mRNA-processing ATP-dependent RNA helicase PRP5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBN2
      Conserved Domains (3) summary
      COG0513
      Location:261 → 607
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:397 → 518
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:260 → 377
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001307557.3 → NP_001294486.1  Pre-mRNA-processing ATP-dependent RNA helicase PRP5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294486.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEV8
      Conserved Domains (3) summary
      COG0513
      Location:261 → 656
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:397 → 518
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:260 → 377
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. NM_001380041.1 → NP_001368269.1  RNA helicase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBH1
      Conserved Domains (1) summary
      cl00098
      Location:140 → 235
      KH-I; K homology (KH) RNA-binding domain, type I
    Nucleotide Protein
    Heading Accession and Version

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