kap-1 Kinesin-associated protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kap-1
Official Full Name: Kinesin-associated protein
Primary source: WormBase:WBGene00002182
Locus tag: CELE_F08F8.3
See related: AllianceGenome:WB:WBGene00002182
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Contributes to microtubule motor activity. Involved in intraciliary anterograde transport; negative regulation of non-motile cilium assembly; and positive regulation of non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of axonemal heterotrimeric kinesin-II complex. Is expressed in body wall musculature; enteric muscle; intestine; and nervous system. Orthologous to human KIFAP3 (kinesin associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See kap-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 15

Sequence:: Chromosome: III; NC_003281.10 (7338835..7343667)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F08F8.3 (e-PCR)
- UniSTS:309604

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinesin binding	IEA Inferred from Electronic Annotation more info
contributes_to microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cilium organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary anterograde transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intraciliary anterograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of axonemal heterotrimeric kinesin-II complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary transition zone	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary transition zone	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Kinesin-associated protein

NP_001367739.1

Confirmed by transcript evidence

NP_001367740.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7338835..7343667

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379791.1 → NP_001367739.1 Kinesin-associated protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KZP1, Q9GV91

Conserved Domains (1) summary

pfam05804
Location:5 → 690

KAP; Kinesin-associated protein (KAP)
NM_001379790.1 → NP_001367740.1 Kinesin-associated protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EEE6, Q9GV91

Conserved Domains (1) summary

pfam05804
Location:5 → 693

KAP; Kinesin-associated protein (KAP)