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    rab-18 Ras-related protein Rab-18 [ Caenorhabditis elegans ]

    Gene ID: 175272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rab-18
    Official Full Name
    Ras-related protein Rab-18
    Primary source
    WormBase:WBGene00004277
    Locus tag
    CELE_Y92C3B.3
    See related
    AllianceGenome:WB:WBGene00004277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport and lipid droplet organization. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in Warburg micro syndrome 3. Orthologous to human RAB18 (RAB18, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rab-18 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (1079466..1080481, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Methyltransf_21 domain-containing protein;Methyltransferase FkbM domain-containing protein Neighboring gene Splicing factor U2AF 65 kDa subunit Neighboring gene ncRNA Neighboring gene KNL (kinetochore null) Binding Protein Neighboring gene RING-type domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The small GTPase RAB-18 is involved in regulating development/diapause by recruiting the intestinal cholesterol transporter NCR-1 onto the apical side in Caenorhabditis elegans. Awazu T, et al. Biochem Biophys Res Commun, 2024 Nov 19. PMID 39232459
    2. Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon. Zorio DA, et al. Mol Cell Biol, 1997 Feb. PMID 9001248, Free PMC Article
    3. C. elegans rab-18 mutants display reduced lipid content under fed and fasted conditions. Ratemi Z, et al. MicroPubl Biol, 2019. PMID 32550463, Free PMC Article
    4. The RBG-1-RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans. Wang Z, et al. J Cell Sci, 2019 Oct 1. PMID 31444285
    5. A Flexible Network of Lipid Droplet Associated Proteins Support Embryonic Integrity of C. elegans. Cao Z, et al. Front Cell Dev Biol, 2022. PMID 35445028, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The small GTPase RAB-18 is involved in regulating development/diapause by recruiting the intestinal cholesterol transporter NCR-1 onto the apical side in Caenorhabditis elegans.
      Title: The small GTPase RAB-18 is involved in regulating development/diapause by recruiting the intestinal cholesterol transporter NCR-1 onto the apical side in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid droplet organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related protein Rab-18
    NP_741092.1
    • Confirmed by transcript evidence
    NP_741093.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1079466..1080481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171081.7 → NP_741092.1  Ras-related protein Rab-18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MXS1, Q9BL22
      Conserved Domains (1) summary
      cd01863
      Location:12 → 172
      Rab18; Rab GTPase family 18 (Rab18)

    2. NM_171861.6 → NP_741093.2  Ras-related protein Rab-18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741093.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MXS1
      Conserved Domains (2) summary
      pfam00071
      Location:1 → 164
      Ras; Ras family
      cl21455
      Location:1 → 162
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MXS1.1

    Gene LinkOut

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