epac-1 Rap guanine nucleotide exchange factor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: epac-1
Official Full Name: Rap guanine nucleotide exchange factor 1
Primary source: WormBase:WBGene00004255
Locus tag: CELE_T20G5.5
See related: AllianceGenome:WB:WBGene00004255
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including RAPGEF3 (Rap guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See epac-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 14

Sequence:: Chromosome: III; NC_003281.10 (10189212..10195405)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T20G5.5 (e-PCR)
- UniSTS:308067

STS3-186 (e-PCR)
- UniSTS:242030

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Rap guanine nucleotide exchange factor 1

NP_499256.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10189212..10195405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066855.5 → NP_499256.2 Rap guanine nucleotide exchange factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499256.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34578

Conserved Domains (5) summary

smart00100
Location:19 → 129

cNMP; Cyclic nucleotide-monophosphate binding domain

smart00147
Location:791 → 1029

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:516 → 654

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00038
Location:375 → 485

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd04437
Location:224 → 353

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...