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    arc-1 E3 ubiquitin-protein ligase arc-1 [ Caenorhabditis elegans ]

    Gene ID: 174525, updated on 4-Jan-2025

    Summary

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    Official Symbol
    arc-1
    Official Full Name
    E3 ubiquitin-protein ligase arc-1
    Primary source
    WormBase:WBGene00000180
    Locus tag
    CELE_ZK1320.6
    See related
    AllianceGenome:WB:WBGene00000180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be active in lysosomal membrane and plasma membrane. Orthologous to human TRIM23 (tripartite motif containing 23). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See arc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (9674978..9677210)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Transcription initiation factor TFIID subunit 8 Neighboring gene G patch domain and ankyrin repeat-containing protein 1 homolog Neighboring gene Purkinje cell protein 4-like protein 1 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Arnoux I, et al. Elife, 2018 Sep 4. PMID 30179155, Free PMC Article
    2. AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Quevedo C, et al. Curr Biol, 2007 Feb 6. PMID 17276923
    3. Analysis of RING finger genes required for embryogenesis in C. elegans. Moore R, et al. Genesis, 2004 Jan. PMID 14755799
    4. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    5. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase arc-1
    NP_496089.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9674978..9677210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063688.9 → NP_496089.3  E3 ubiquitin-protein ligase arc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496089.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09654
      Conserved Domains (6) summary
      smart00502
      Location:208 → 339
      BBC; B-Box C-terminal domain
      cd00878
      Location:371 → 526
      Arf_Arl; ADP-ribosylation factor(Arf)/Arf-like (Arl) small GTPases
      TIGR00231
      Location:371 → 526
      small_GTP; small GTP-binding protein domain
      pfam00643
      Location:105 → 149
      zf-B_box; B-box zinc finger
      pfam01442
      Location:201 → 306
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam14634
      Location:6 → 54
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09654.3

    Gene LinkOut

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