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    etc-1 E3 ubiquitin-protein ligase etc-1 [ Caenorhabditis elegans ]

    Gene ID: 174388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    etc-1
    Official Full Name
    E3 ubiquitin-protein ligase etc-1
    Primary source
    WormBase:WBGene00008429
    Locus tag
    CELE_D2085.4
    See related
    AllianceGenome:WB:WBGene00008429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin protein ligase activity. Involved in positive regulation of metaphase/anaphase transition of meiotic cell cycle; regulation of metaphase/anaphase transition of meiosis II; and ubiquitin-dependent protein catabolic process. Orthologous to human UBE3C (ubiquitin protein ligase E3C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See etc-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    15
    Sequence:
    Chromosome: II; NC_003280.10 (8664833..8669154)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Translation initiation factor eIF2B subunit epsilon Neighboring gene Ubiquitin-like-conjugating enzyme ATG10 Neighboring gene PIGA GPI anchor biosynthesis domain-containing protein Neighboring gene Ral GTPase-activating protein subunit alpha/beta N-terminal domain-containing protein;Rap-GAP domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin ligases and a processive proteasome facilitate protein clearance during the oocyte-to-embryo transition in Caenorhabditis elegans. Spike CA, et al. Genetics, 2022 May 5. PMID 35377419, Free PMC Article
    2. HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans. Wang R, et al. Development, 2013 May. PMID 23578927
    3. Influences of HLH-2 stability on anchor cell fate specification during Caenorhabditis elegans gonadogenesis. Benavidez JM, et al. G3 (Bethesda), 2022 Apr 4. PMID 35134193, Free PMC Article
    4. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBC-18 plays a distinct role together with ETC-1 in regulating the cytoplasmic level of IFY-1 during meiosis in C. elegans
      Title: HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of metaphase/anaphase transition of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of metaphase/anaphase transition of meiosis II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase etc-1
    NP_495842.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8664833..8669154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063441.5 → NP_495842.1  E3 ubiquitin-protein ligase etc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17736, Q18992
      Conserved Domains (1) summary
      smart00119
      Location:661 → 998
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O17736.1

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