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    pcyt-2.2 ethanolamine-phosphate cytidylyltransferase [ Caenorhabditis elegans ]

    Gene ID: 181047, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pcyt-2.2
    Official Full Name
    ethanolamine-phosphate cytidylyltransferase
    Primary source
    WormBase:WBGene00016531
    Locus tag
    CELE_C39D10.3
    See related
    AllianceGenome:WB:WBGene00016531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ethanolamine-phosphate cytidylyltransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 82. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pcyt-2.2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (7884294..7887479)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene 'chromo' domain containing protein Neighboring gene Lysosomal-Associated Transmembrane Domain containing

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ethanolamine-phosphate cytidylyltransferase
    NP_001041226.2
    • Confirmed by transcript evidence
    NP_001041227.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7884294..7887479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047761.6 → NP_001041226.2  ethanolamine-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041226.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18524
      Conserved Domains (1) summary
      PTZ00308
      Location:19 → 284
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    2. NM_001047762.5 → NP_001041227.1  ethanolamine-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UVJ6
      Conserved Domains (1) summary
      cl00015
      Location:59 → 193
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version

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