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    mttu-1 putative mitochondrial tRNA-specific 2-thiouridylase 1 [ Caenorhabditis elegans ]

    Gene ID: 178038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mttu-1
    Official Full Name
    putative mitochondrial tRNA-specific 2-thiouridylase 1
    Primary source
    WormBase:WBGene00007114
    Locus tag
    CELE_B0035.16
    See related
    AllianceGenome:WB:WBGene00007114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; tRNA binding activity; and tRNA-5-taurinomethyluridine 2-sulfurtransferase. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in aminoglycoside-induced deafness; infantile liver failure syndrome; and transient infantile liver failure. Orthologous to human TRMU (tRNA mitochondrial 2-thiouridylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mttu-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    7
    Sequence:
    Chromosome: IV; NC_003282.8 (11295077..11296887, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Caenorhabditis elegans orthologs of human genes required for mitochondrial tRNA modification cause similar electron transport chain defects but different nuclear responses. Navarro-González C, et al. PLoS Genet, 2017 Jul. PMID 28732077, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-5-taurinomethyluridine 2-sulfurtransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    putative mitochondrial tRNA-specific 2-thiouridylase 1
    NP_502120.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11295077..11296887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069719.5 → NP_502120.1  putative mitochondrial tRNA-specific 2-thiouridylase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502120.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17440
      Conserved Domains (2) summary
      cd01998
      Location:3 → 368
      tRNA_Me_trans; tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs. ...
      pfam03054
      Location:3 → 368
      tRNA_Me_trans; tRNA methyl transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17440.2

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