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    xbx-6 Protein lifeguard 1-like [ Caenorhabditis elegans ]

    Gene ID: 179361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xbx-6
    Official Full Name
    Protein lifeguard 1-like
    Primary source
    WormBase:WBGene00009580
    Locus tag
    CELE_F40F9.1
    See related
    AllianceGenome:WB:WBGene00009580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of neuron apoptotic process. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary muscle; nervous system; pharynx; reproductive system; and tail. Orthologous to several human genes including GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See xbx-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (9703055..9707835)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene RNA_ligase domain-containing protein Neighboring gene Protein her-1 Neighboring gene Transmembrane BAX inhibitor motif-containing protein 4 Neighboring gene tRNA wybutosine-synthesizing protein 2 homolog Neighboring gene ncRNA Neighboring gene PDZ domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fas-apoptotic inhibitory molecule 2 localizes to the lysosome and facilitates autophagosome-lysosome fusion through the LC3 interaction region motif-dependent interaction with LC3. Hong CJ, et al. FASEB J, 2020 Jan. PMID 31914609
    2. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
    3. Analysis of xbx genes in C. elegans. Efimenko E, et al. Development, 2005 Apr. PMID 15790967
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein lifeguard 1-like
    NP_001379309.1
    • Confirmed by transcript evidence
    NP_741597.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9703055..9707835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392582.1 → NP_001379309.1  Protein lifeguard 1-like [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ55
      Conserved Domains (1) summary
      cd10428
      Location:74 → 293
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    2. NM_171511.8 → NP_741597.1  Protein lifeguard 1-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741597.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ56
      Conserved Domains (1) summary
      cd10428
      Location:74 → 293
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis

    RNA

    1. NR_069217.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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