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    gla-3 C3H1-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172604, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gla-3
    Official Full Name
    C3H1-type domain-containing protein
    Primary source
    WormBase:WBGene00011376
    Locus tag
    CELE_T02E1.3
    See related
    AllianceGenome:WB:WBGene00011376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Located in cell cortex. Is expressed in germ line; muscle cell; and somatic cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gla-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (8214376..8217996)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Calmodulin-binding domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein Neighboring gene Protein dhs-3 Neighboring gene Fungal_trans domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans GLA-3 is a novel component of the MAP kinase MPK-1 signaling pathway required for germ cell survival. Kritikou EA, et al. Genes Dev, 2006 Aug 15. PMID 16912277, Free PMC Article
    2. Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Perrin AJ, et al. Cell Death Differ, 2013 Jan. PMID 22935616, Free PMC Article
    3. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Chen D, et al. Science, 2010 Mar 5. PMID 20133524
    4. The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity. Bailly AP, et al. Cell Rep, 2019 Oct 1. PMID 31577950, Free PMC Article
    5. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C3H1-type domain-containing protein
    NP_001250706.1
    • Confirmed by transcript evidence
    NP_492238.2
    • Confirmed by transcript evidence
    NP_492239.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8214376..8217996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001263777.3 → NP_001250706.1  C3H1-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9WRT8
      Conserved Domains (1) summary
      pfam00642
      Location:35 → 61
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    2. NM_059837.7 → NP_492238.2  C3H1-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492238.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4JFB7
      Conserved Domains (1) summary
      pfam00642
      Location:37 → 63
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    3. NM_059838.4 → NP_492239.1  C3H1-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492239.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02289
      Conserved Domains (1) summary
      pfam00642
      Location:71 → 96
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    Nucleotide Protein
    Heading Accession and Version

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