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    sup-26 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sup-26
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00006331
    Locus tag
    CELE_R10E4.2
    See related
    AllianceGenome:WB:WBGene00006331
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in negative regulation of translation. Located in cytoplasm. Is expressed in several structures, including germ line and gonad. Orthologous to human RBMS1 (RNA binding motif single stranded interacting protein 1); RBMS2 (RNA binding motif single stranded interacting protein 2); and RBMS3 (RNA binding motif single stranded interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sup-26 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (4276196..4280224, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Splicing factor 3B subunit 1 domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The embryonic mir-35 family of microRNAs promotes multiple aspects of fecundity in Caenorhabditis elegans. McJunkin K, et al. G3 (Bethesda), 2014 Jul 21. PMID 25053708, Free PMC Article
    2. microRNA regulation of the embryonic hypoxic response in Caenorhabditis elegans. Kagias K, et al. Sci Rep, 2015 Jun 11. PMID 26063315, Free PMC Article
    3. Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development. Schachtner LT, et al. Dev Genes Evol, 2015 Nov. PMID 26271810
    4. The developmentally timed decay of an essential microRNA family is seed-sequence dependent. Donnelly BF, et al. Cell Rep, 2022 Aug 9. PMID 35947946, Free PMC Article
    5. A microRNA family exerts maternal control on sex determination in C. elegans. McJunkin K, et al. Genes Dev, 2017 Feb 15. PMID 28279983, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_001022716.1
    • Confirmed by transcript evidence
    NP_001254892.1
    • Confirmed by transcript evidence
    NP_001254893.1
    • Confirmed by transcript evidence
    NP_001254894.1
    • Confirmed by transcript evidence
    NP_001254898.1
    • Confirmed by transcript evidence
    NP_001254900.1
    • Confirmed by transcript evidence
    NP_001254903.1
    • Confirmed by transcript evidence
    NP_001364668.1
    • Confirmed by transcript evidence
    NP_001367243.1
    • Confirmed by transcript evidence
    NP_001367244.1
    • Partially confirmed by transcript evidence
    NP_001367245.1
    • Confirmed by transcript evidence
    NP_001367246.1
    • Confirmed by transcript evidence
    NP_001379085.1
    • Confirmed by transcript evidence
    NP_001379516.1
    • Confirmed by transcript evidence
    NP_001379517.1
    • Confirmed by transcript evidence
    NP_497855.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4276196..4280224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267971.4 → NP_001254900.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254900.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ1
      Conserved Domains (2) summary
      cd12243
      Location:81 → 151
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:162 → 243
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    2. NM_001381832.2 → NP_001367243.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ3
      Conserved Domains (3) summary
      TIGR01648
      Location:141 → 405
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd12243
      Location:107 → 177
      RRM1_MSSP; RNA recognition motif 1 (RRM1) found in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:188 → 269
      RRM2_MSSP; RNA recognition motif 2 (RRM2) found in the c-myc gene single-strand binding proteins (MSSP) family

    3. NM_001393318.1 → NP_001379516.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ2
      Conserved Domains (3) summary
      TIGR01648
      Location:141 → 379
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd12243
      Location:107 → 177
      RRM1_MSSP; RNA recognition motif 1 (RRM1) found in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:188 → 269
      RRM2_MSSP; RNA recognition motif 2 (RRM2) found in the c-myc gene single-strand binding proteins (MSSP) family

    4. NM_065454.7 → NP_497855.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21900
      Conserved Domains (2) summary
      cd12243
      Location:107 → 177
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:188 → 269
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    5. NM_001267974.3 → NP_001254903.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCP9

    6. NM_001393317.1 → NP_001379085.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JMB8
      Conserved Domains (2) summary
      cd12243
      Location:81 → 151
      RRM1_MSSP; RNA recognition motif 1 (RRM1) found in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:162 → 243
      RRM2_MSSP; RNA recognition motif 2 (RRM2) found in the c-myc gene single-strand binding proteins (MSSP) family

    7. NM_001267963.3 → NP_001254892.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCR3
      Conserved Domains (2) summary
      cd12243
      Location:148 → 218
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:229 → 310
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    8. NM_001267964.3 → NP_001254893.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCR5
      Conserved Domains (2) summary
      cd12243
      Location:43 → 113
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:124 → 205
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    9. NM_001267965.3 → NP_001254894.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ8
      Conserved Domains (2) summary
      cd12243
      Location:43 → 113
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:124 → 205
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    10. NM_001381827.1 → NP_001367246.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ7
      Conserved Domains (2) summary
      cd12243
      Location:81 → 151
      RRM1_MSSP; RNA recognition motif 1 (RRM1) found in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:162 → 243
      RRM2_MSSP; RNA recognition motif 2 (RRM2) found in the c-myc gene single-strand binding proteins (MSSP) family

    11. NM_001381828.3 → NP_001367245.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ6
      Conserved Domains (2) summary
      cd12243
      Location:107 → 177
      RRM1_MSSP; RNA recognition motif 1 (RRM1) found in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:188 → 269
      RRM2_MSSP; RNA recognition motif 2 (RRM2) found in the c-myc gene single-strand binding proteins (MSSP) family

    12. NM_001381829.1 → NP_001367244.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ5
      Conserved Domains (2) summary
      cd12243
      Location:107 → 177
      RRM1_MSSP; RNA recognition motif 1 (RRM1) found in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:188 → 269
      RRM2_MSSP; RNA recognition motif 2 (RRM2) found in the c-myc gene single-strand binding proteins (MSSP) family

    13. NM_001267969.1 → NP_001254898.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254898.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCR4
      Conserved Domains (2) summary
      cd12243
      Location:148 → 218
      RRM1_MSSP; RNA recognition motif 1 in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:229 → 310
      RRM2_MSSP; RNA recognition motif 2 in the c-myc gene single-strand binding proteins (MSSP) family

    14. NM_001027545.4 → NP_001022716.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z204

    15. NM_001393316.1 → NP_001379517.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ4
      Conserved Domains (3) summary
      TIGR01648
      Location:77 → 315
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd12243
      Location:43 → 113
      RRM1_MSSP; RNA recognition motif 1 (RRM1) found in the c-myc gene single-strand binding proteins (MSSP) family
      cd12244
      Location:124 → 205
      RRM2_MSSP; RNA recognition motif 2 (RRM2) found in the c-myc gene single-strand binding proteins (MSSP) family

    16. NM_001377919.2 → NP_001364668.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCQ0
    Nucleotide Protein
    Heading Accession and Version

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