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    ifa-4 Intermediate filament protein ifa-4 [ Caenorhabditis elegans ]

    Gene ID: 180765, updated on 9-Dec-2024

    Summary

    Official Symbol
    ifa-4
    Official Full Name
    Intermediate filament protein ifa-4
    Primary source
    WormBase:WBGene00002052
    Locus tag
    CELE_K05B2.3
    See related
    AllianceGenome:WB:WBGene00002052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in several structures, including egg-laying apparatus; excretory cell; pharyngeal-intestinal valve; rectum; and spermathecal-uterine valve cell. Human ortholog(s) of this gene implicated in partial lipodystrophy; primary autosomal recessive microcephaly; and progressive myoclonus epilepsy 9. Orthologous to human LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ifa-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (4912308..4915979, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RAB6-interacting golgin;Ras-associating domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acyl-coenzyme A thioesterase 1-like

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Intermediate filament protein ifa-4
    NP_508836.5
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4912308..4915979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076435.10NP_508836.5  Intermediate filament protein ifa-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508836.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90900, Q9GYN4
      Conserved Domains (3) summary
      pfam00038
      Location:70422
      Filament; Intermediate filament protein
      pfam00932
      Location:463569
      LTD; Lamin Tail Domain
      cl19219
      Location:135254
      DUF342; Protein of unknown function (DUF342)