gsp-1 Serine/threonine-protein phosphatase PP1-alpha [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gsp-1
Official Full Name: Serine/threonine-protein phosphatase PP1-alpha
Primary source: WormBase:WBGene00001747
Locus tag: CELE_F29F11.6
See related: AllianceGenome:WB:WBGene00001747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine phosphatase activity. Involved in negative regulation of protein phosphorylation and positive regulation of gene expression. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including anal sphincter muscle; excretory cell; nervous system; oocyte; and reproductive system. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gsp-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (10682422..10686537)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos.
Title: PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos.
the cell can exit the division without reforming the nuclear envelope to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore
Title: A Nucleoporin at the Meiotic Kinetochore.
Protein phosphatase 1 is a critical regulator of ZYG-1. When protein phosphatase 1 is down-regulated, ZYG-1 levels increase leading to centrosome amplification.
Title: Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F29F11.6 (e-PCR)
- UniSTS:314163

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Serine/threonine-protein phosphatase PP1-alpha

NP_001256250.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10682422..10686537

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269321.4 → NP_001256250.1 Serine/threonine-protein phosphatase PP1-alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256250.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q27497

Conserved Domains (1) summary

cd07414
Location:8 → 298

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain