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    nkat-3 kynurenine--oxoglutarate transaminase [ Caenorhabditis elegans ]

    Gene ID: 181633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nkat-3
    Official Full Name
    kynurenine--oxoglutarate transaminase
    Primary source
    WormBase:WBGene00010984
    Locus tag
    CELE_R03A10.4
    See related
    AllianceGenome:WB:WBGene00010984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kynurenine-oxoglutarate transaminase activity. Predicted to be involved in L-kynurenine metabolic process and biosynthetic process. Predicted to be active in mitochondrion. Is expressed in gonad; neurons; pharyngeal muscle cell; and tail. Orthologous to several human genes including KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nkat-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (15441731..15443630)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene Molybdenum cofactor sulfurase Neighboring gene ncRNA Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. Yu P, et al. Gene, 2006 Jan 3. PMID 16376499
    2. MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Bender LB, et al. Development, 2006 Oct. PMID 16968818, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-kynurenine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine--oxoglutarate transaminase
    NP_001024822.1
    • Confirmed by transcript evidence
    NP_001024823.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15441731..15443630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029651.6 → NP_001024822.1  kynurenine--oxoglutarate transaminase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MP09
      Conserved Domains (1) summary
      PRK08912
      Location:44 → 435
      PRK08912; aminotransferase

    2. NM_001029652.7 → NP_001024823.1  kynurenine--oxoglutarate transaminase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024823.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5FC69
      Conserved Domains (1) summary
      PRK08912
      Location:27 → 418
      PRK08912; aminotransferase
    Nucleotide Protein
    Heading Accession and Version

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