sod-2 Superoxide dismutase [Mn] 1, mitochondrial [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: sod-2
Official Full Name: Superoxide dismutase [Mn] 1, mitochondrial
Primary source: WormBase:WBGene00004931
Locus tag: CELE_F10D11.1
See related: AllianceGenome:WB:WBGene00004931
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein homodimerization activity and superoxide dismutase activity. Involved in removal of superoxide radicals. Located in mitochondrion. Part of respiratory chain complex. Is expressed in head and tail. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See sod-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (8434550..8435807)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that SOD-2 plays an important role in the sperm activation of C. elegans by producing H2O2 as an activator of pseudopod extension
Title: Hydrogen peroxide produced by superoxide dismutase SOD-2 activates sperm in Caenorhabditis elegans.
Interactions of the mitochondrial superoxide dismutases (mtSODs): SOD-2 and SOD-3, are reported.
Title: Novel interactions between mitochondrial superoxide dismutases and the electron transport chain.
Damage levels in the mtDNA of SOD mutants are not significantly different from those in wild-type animals, i.e. even the total loss of mitochondrial SOD did not significantly increase oxidative damage to mtDNA.
Title: Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?
increased oxidative stress caused by deletion of sod genes does not result in decreased lifespan in C. elegans and that deletion of sod-2 extends worm lifespan by altering mitochondrial function
Title: Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.
identify and analyze the sequence and structure characteristics that ensure the cofactor specificities and the oligomerization modes
Title: Mn/Fe superoxide dismutase interaction fingerprints and prediction of oligomerization and metal cofactor from sequence.
although several long-lived mutants of Caenorhabditis elegans have increased SOD levels, this phenomenon does not correlate with life span or growth rate.
Title: A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F10D11.1 (e-PCR)
- UniSTS:315691

F02E9.8 (e-PCR)
- UniSTS:309564

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Superoxide dismutase [Mn] 1, mitochondrial

NP_492290.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8434550..8435807

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059889.7 → NP_492290.1 Superoxide dismutase [Mn] 1, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492290.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P31161

Conserved Domains (3) summary

COG0605
Location:23 → 219

SodA; Superoxide dismutase [Inorganic ion transport and metabolism]

pfam00081
Location:25 → 106

Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain

pfam02777
Location:112 → 215

Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain