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    pax-1 Paired box protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 187105, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pax-1
    Official Full Name
    Paired box protein 1 homolog
    Primary source
    WormBase:WBGene00003937
    Locus tag
    CELE_K07C11.1
    See related
    AllianceGenome:WB:WBGene00003937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to Gram-negative bacterium. Located in nucleus. Is expressed in epithelial cell and pharyngeal cell. Human ortholog(s) of this gene implicated in branchiootorenal syndrome and tooth agenesis. Orthologous to several human genes including PAX9 (paired box 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pax-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (8224934..8226116)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Aurora kinase Neighboring gene ncRNA Neighboring gene BBSome-interacting protein 1 Neighboring gene ncRNA Neighboring gene Protein roller-3 Neighboring gene ncRNA Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA. Fakhouri TH, et al. PLoS Genet, 2010 Aug 12. PMID 20714352, Free PMC Article
    2. Pax genes in Caenorhabditis elegans: a new twist. Hobert O, et al. Trends Genet, 1999 Jun. PMID 10354580
    3. Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans. Sahu SN, et al. PLoS One, 2012. PMID 22675448, Free PMC Article
    4. Temporal regulation of foregut development by HTZ-1/H2A.Z and PHA-4/FoxA. Updike DL, et al. PLoS Genet, 2006 Sep 29. PMID 17009877, Free PMC Article
    5. In vitro and in vivo characterization of Caenorhabditis elegans PHA-4/FoxA response elements. Raharjo WH, et al. Dev Dyn, 2010 Aug. PMID 20623595

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Paired box protein 1 homolog
    NP_505120.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8224934..8226116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072719.2 → NP_505120.1  Paired box protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505120.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21272
      Conserved Domains (1) summary
      smart00351
      Location:61 → 185
      PAX; Paired Box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21272.1

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