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    pkg-2 Protein kinase domain-containing protein;cGMP-dependent protein kinase [ Caenorhabditis elegans ]

    Gene ID: 177659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pkg-2
    Official Full Name
    Protein kinase domain-containing protein;cGMP-dependent protein kinase
    Primary source
    WormBase:WBGene00015650
    Locus tag
    CELE_C09G4.2
    See related
    AllianceGenome:WB:WBGene00015650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to be involved in receptor guanylyl cyclase signaling pathway. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pkg-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (8520894..8538187)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Cyclin-dependent kinases regulatory subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ceramide synthase hyl-1;TLC domain-containing protein Neighboring gene Neuropeptide receptor 22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of C. elegans. Olson A, et al. MicroPubl Biol, 2019 May 24. PMID 32550449, Free PMC Article
    2. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Lehner B, et al. Nat Genet, 2006 Aug. PMID 16845399
    3. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cGMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic nucleotide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein;cGMP-dependent protein kinase
    NP_741467.1
    • Confirmed by transcript evidence
    NP_741468.1
    • Confirmed by transcript evidence
    NP_741469.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8520894..8538187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171401.10 → NP_741467.1  cGMP-dependent protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741467.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYN2
      Conserved Domains (4) summary
      PTZ00263
      Location:295 → 599
      PTZ00263; protein kinase A catalytic subunit; Provisional
      COG0664
      Location:66 → 173
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:72 → 173
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:316 → 572
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

    2. NM_171402.6 → NP_741468.1  cGMP-dependent protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741468.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYN1
      Conserved Domains (4) summary
      PTZ00263
      Location:259 → 563
      PTZ00263; protein kinase A catalytic subunit; Provisional
      COG0664
      Location:30 → 137
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:36 → 137
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:280 → 536
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

    3. NM_171403.6 → NP_741469.2  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741469.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQE2
      Conserved Domains (2) summary
      smart00133
      Location:293 → 344
      S_TK_X; Extension to Ser/Thr-type protein kinases
      cd05572
      Location:43 → 299
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    Nucleotide Protein
    Heading Accession and Version

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