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    inx-14 Innexin-14 [ Caenorhabditis elegans ]

    Gene ID: 172488, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inx-14
    Official Full Name
    Innexin-14
    Primary source
    WormBase:WBGene00002136
    Locus tag
    CELE_F07A5.1
    See related
    AllianceGenome:WB:WBGene00002136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable gap junction hemi-channel activity. Acts upstream of or within with a positive effect on germ cell proliferation. Acts upstream of or within with a negative effect on oocyte maturation. Located in gap junction. Is expressed in several structures, including GABAergic neurons; germ cell; germ line; non-striated muscle; and somatic gonad precursor. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See inx-14 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (7350309..7352235, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Globin domain-containing protein Neighboring gene Glycine cleavage system H protein Neighboring gene NF-kappa-B inhibitor-interacting Ras-like protein Neighboring gene Expressed conserved protein Neighboring gene SCAVenger receptor (CD36 family) related Neighboring gene Olfactomedin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gonadal gap junction INX-14/Notch GLP-1 signaling axis suppresses gut defense through an intestinal lysosome pathway. Zhang X, et al. Front Immunol, 2023. PMID 37928537, Free PMC Article
    2. The gap junctional protein INX-14 functions in oocyte precursors to promote C. elegans sperm guidance. Edmonds JW, et al. Dev Biol, 2011 Nov 1. PMID 21889935, Free PMC Article
    3. A Limited and Diverse Set of Suppressor Mutations Restore Function to INX-8 Mutant Hemichannels in the Caenorhabditis elegans Somatic Gonad. Starich T, et al. Biomolecules, 2020 Dec 10. PMID 33321846, Free PMC Article
    4. Two classes of gap junction channels mediate soma-germline interactions essential for germline proliferation and gametogenesis in Caenorhabditis elegans. Starich TA, et al. Genetics, 2014 Nov. PMID 25195067, Free PMC Article
    5. Somatic cAMP signaling regulates MSP-dependent oocyte growth and meiotic maturation in C. elegans. Govindan JA, et al. Development, 2009 Jul. PMID 19502483, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A gonadal gap junction INX-14/Notch GLP-1 signaling axis suppresses gut defense through an intestinal lysosome pathway.
      Title: A gonadal gap junction INX-14/Notch GLP-1 signaling axis suppresses gut defense through an intestinal lysosome pathway.
    2. results support the model that INX-14 functions in a somatic gonad/germ cell signaling mechanism essential for sperm function
      Title: The gap junctional protein INX-14 functions in oocyte precursors to promote C. elegans sperm guidance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_negative_effect oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Innexin-14
    NP_492078.1
    • Confirmed by transcript evidence
    NP_492079.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7350309..7352235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059678.6 → NP_492079.1  Innexin-14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492079.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62136
      Conserved Domains (1) summary
      pfam00876
      Location:24 → 397
      Innexin; Innexin

    2. NM_059677.7 → NP_492078.1  Innexin-14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62136, Q19139
      Conserved Domains (1) summary
      pfam00876
      Location:24 → 397
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62136.1

    Gene LinkOut

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