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    cars-1 Cysteine--tRNA ligase, cytoplasmic [ Caenorhabditis elegans ]

    Gene ID: 171821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cars-1
    Official Full Name
    Cysteine--tRNA ligase, cytoplasmic
    Primary source
    WormBase:WBGene00000800
    Locus tag
    CELE_Y23H5A.7
    See related
    AllianceGenome:WB:WBGene00000800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cars-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (2623099..2628112, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Protein pid-3 Neighboring gene Cnn_1N domain-containing protein;t-SNARE coiled-coil homology domain-containing protein Neighboring gene pseudo Neighboring gene NADH dehydrogenase subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    2. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cysteine--tRNA ligase, cytoplasmic
    NP_001293288.1
    • Partially confirmed by transcript evidence
    NP_491014.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2623099..2628112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058613.7 → NP_491014.2  Cysteine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QD27, Q965I6

    2. NM_001306359.3 → NP_001293288.1  Cysteine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACL3, O76618
      Conserved Domains (1) summary
      PTZ00399
      Location:16 → 754
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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