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    C32F10.8 alanine transaminase [ Caenorhabditis elegans ]

    Gene ID: 172252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C32F10.8
    Official Full Name
    alanine transaminase
    Primary source
    WormBase:WBGene00016333
    Locus tag
    CELE_C32F10.8
    See related
    AllianceGenome:WB:WBGene00016333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Predicted to be involved in L-alanine catabolic process and biosynthetic process. Is expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT (glutamic--pyruvic transaminase) and GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See C32F10.8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (5822982..5826148, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Retinoblastoma-like protein homolog lin-35 Neighboring gene FACT complex subunit ssrp1-B Neighboring gene Nuclear hormone receptor family member nhr-2 Neighboring gene ncRNA Neighboring gene Oxysterol-binding protein Neighboring gene Potassium channel domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    2. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alanine transaminase
    NP_001359801.1
    • Confirmed by transcript evidence
    NP_001370337.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5822982..5826148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001372883.4 → NP_001359801.1  alanine transaminase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01685
      Conserved Domains (1) summary
      PTZ00377
      Location:25 → 504
      PTZ00377; alanine aminotransferase; Provisional

    2. NM_001383155.2 → NP_001370337.1  alanine transaminase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86GU3
      Conserved Domains (1) summary
      PTZ00377
      Location:25 → 345
      PTZ00377; alanine aminotransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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