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    gck-4 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181488, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gck-4
    Official Full Name
    Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00007287
    Locus tag
    CELE_C04A11.3
    See related
    AllianceGenome:WB:WBGene00007287
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm. Is expressed in excretory cell; head; intestine; pharynx; and tail. Orthologous to human SLK (STE20 like kinase) and STK10 (serine/threonine kinase 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gck-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (13677192..13682340)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Disintegrin and metalloproteinase domain-containing protein adm-2 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics. Knox J, et al. Sci Rep, 2021 Apr 28. PMID 33911106, Free PMC Article
    2. Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle. Qadota H, et al. Mol Biol Cell, 2018 Aug 15. PMID 29949401, Free PMC Article
    3. The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. Franziscus CA, et al. FEBS Open Bio, 2024 Mar. PMID 38320757, Free PMC Article
    4. Identification of innate immunity genes and pathways using a comparative genomics approach. Alper S, et al. Proc Natl Acad Sci U S A, 2008 May 13. PMID 18463287, Free PMC Article
    5. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Fridolfsson HN, et al. Dev Biol, 2010 Feb 15. PMID 20005871, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein
    NP_001360654.1
    • Confirmed by transcript evidence
    NP_510290.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13677192..13682340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077889.5 → NP_510290.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510290.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17566
      Conserved Domains (2) summary
      cd06611
      Location:28 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      pfam12474
      Location:862 → 995
      PKK; Polo kinase kinase

    2. NM_001373560.5 → NP_001360654.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKG6
      Conserved Domains (2) summary
      cd06611
      Location:28 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      pfam12474
      Location:862 → 995
      PKK; Polo kinase kinase
    Nucleotide Protein
    Heading Accession and Version

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