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    him-8 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    him-8
    Official Full Name
    C2H2-type domain-containing protein
    Primary source
    WormBase:WBGene00001867
    Locus tag
    CELE_T07G12.12
    See related
    AllianceGenome:WB:WBGene00001867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in meiotic chromosome segregation. Located in X chromosome; condensed nuclear chromosome; and nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See him-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (10561905..10563974)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The synaptonemal complexes of Caenorhabditis elegans: the dominant him mutant mnT6 and pachytene karyotype analysis of the X-autosome translocation. Goldstein P. Chromosoma, 1986. PMID 3948601
    2. HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis. Phillips CM, et al. Cell, 2005 Dec 16. PMID 16360035, Free PMC Article
    3. Why are there males in the hermaphroditic species Caenorhabditis elegans? Chasnov JR, et al. Genetics, 2002 Mar. PMID 11901116, Free PMC Article
    4. Chromosome painting reveals asynaptic full alignment of homologs and HIM-8-dependent remodeling of X chromosome territories during Caenorhabditis elegans meiosis. Nabeshima K, et al. PLoS Genet, 2011 Aug. PMID 21876678, Free PMC Article
    5. Cell-specific transcriptional regulation of the major sperm protein in Caenorhabditis elegans. Klass M, et al. Dev Biol, 1982 Sep. PMID 7128929

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HIM-8 functions both at and outside of chromosome pairing centers to mediate chromosome territory elongation.
      Title: Chromosome painting reveals asynaptic full alignment of homologs and HIM-8-dependent remodeling of X chromosome territories during Caenorhabditis elegans meiosis.
    2. Results show that short sequence elements enriched in the corresponding chromosome regions selectively recruit ZIM-1, 2, 3 and HIM-8 pairing centres in vivo.
      Title: Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans.
    3. mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8
      Title: Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related Zinc-Finger ZIM proteins.
    4. Him-8 protein is a product of the T07G12.12 gene, and plays an essential role in X-chromosome meiotic synapsis.
      Title: HIM-8 binds to the X chromosome pairing center and mediates chromosome-specific meiotic synapsis.
    5. the wild-type him-8 gene product acts antagonistically to EGL-13
      Title: C. elegans HIM-8 functions outside of meiosis to antagonize EGL-13 Sox protein function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in meiotic chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in X chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein
    NP_001255493.1
    • Confirmed by transcript evidence
    NP_001370042.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10561905..10563974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383193.2 → NP_001370042.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18068

    2. NM_001268564.3 → NP_001255493.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255493.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUH4
    Nucleotide Protein
    Heading Accession and Version

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