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    acs-7 Acyl-CoA synthetase 7 [ Caenorhabditis elegans ]

    Gene ID: 174472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-7
    Official Full Name
    Acyl-CoA synthetase 7
    Primary source
    WormBase:WBGene00007228
    Locus tag
    CELE_C01G6.7
    See related
    AllianceGenome:WB:WBGene00007228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables medium-chain fatty acid-CoA ligase activity. Involved in ascaroside biosynthetic process. Located in peroxisome. Is expressed in intestinal cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (9292017..9294033)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Methionine synthase reductase Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Golgi apparatus protein 1 Neighboring gene Tyrosine-protein kinase receptor cam-1 Neighboring gene ncRNA Neighboring gene WD_REPEATS_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of Modular Ascarosides in C. elegans. Panda O, et al. Angew Chem Int Ed Engl, 2017 Apr 18. PMID 28371259, Free PMC Article
    2. A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones. Faghih N, et al. J Am Chem Soc, 2020 Aug 12. PMID 32702987, Free PMC Article
    3. Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans. Zhou Y, et al. Elife, 2018 Jun 4. PMID 29863473, Free PMC Article
    4. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article
    5. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CoA-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascaroside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA synthetase 7
    NP_495979.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9292017..9294033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063578.7 → NP_495979.1  Acyl-CoA synthetase 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17577
      Conserved Domains (1) summary
      cd05911
      Location:35 → 524
      Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17577.1

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