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    klo-1 Glycoside hydrolase family 1 protein [ Caenorhabditis elegans ]

    Gene ID: 177557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klo-1
    Official Full Name
    Glycoside hydrolase family 1 protein
    Primary source
    WormBase:WBGene00016848
    Locus tag
    CELE_C50F7.10
    See related
    AllianceGenome:WB:WBGene00016848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in excretory cell and intestine. Used to study kidney disease. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to several human genes including GBA3 (glucosylceramidase beta 3 (gene/pseudogene)) and LCTL (lactase like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See klo-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (7745979..7748071, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Basic proline-rich protein-like Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Peroxidase Neighboring gene ncRNA Neighboring gene Cuticle collagen 14;Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans. Dueñas M, et al. Pharmacol Res, 2013 Oct. PMID 23856528
    2. The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans. Polanska UM, et al. J Biol Chem, 2011 Feb 18. PMID 21177529, Free PMC Article
    3. KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. Xu C, et al. EMBO Mol Med, 2017 Oct. PMID 28754744, Free PMC Article
    4. A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans. Tang J, et al. Biochem Biophys Res Commun, 2021 Jul 12. PMID 34034091
    5. FGF23 signalling and physiology. Ho BB, et al. J Mol Endocrinol, 2021 Feb. PMID 33338030, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans.
      Title: A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans.
    2. findings indicate that a predicted KL1 isoform of Klotho requires the FGF signalling pathway to crosstalk with the Daf-2/insulin/Igf-like pathway, in order to regulate aging and oxidative stress resistance
      Title: Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glycoside hydrolase family 1 protein
    NP_501271.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7745979..7748071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068870.7 → NP_501271.1  Glycoside hydrolase family 1 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18758
      Conserved Domains (1) summary
      cl23725
      Location:7 → 470
      Glyco_hydro_1; Glycosyl hydrolase family 1
    Nucleotide Protein
    Heading Accession and Version

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