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    rilp-1 RILP-like protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rilp-1
    Official Full Name
    RILP-like protein 1
    Primary source
    WormBase:WBGene00007860
    Locus tag
    CELE_C32A3.3
    See related
    AllianceGenome:WB:WBGene00007860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Predicted to be involved in cilium assembly. Predicted to be located in membrane. Predicted to be active in ciliary basal body and cytoplasm. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 4. Orthologous to human RILPL1 (Rab interacting lysosomal protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rilp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (3636144..3643669)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative potassium channel regulatory protein unc-93 Neighboring gene MADF domain-containing protein Neighboring gene Glutathione reductase, mitochondrial Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved autoimmune-disease risk gene TMEM39A regulates lysosome dynamics. Luo S, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33531362, Free PMC Article
    2. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
    3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    4. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables MAP-kinase scaffold activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RILP-like protein 1
    NP_741113.3
    • Confirmed by transcript evidence
    NP_741114.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3636144..3643669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171100.9 → NP_741113.3  RILP-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741113.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFB9
      Conserved Domains (5) summary
      pfam07200
      Location:165 → 290
      Mod_r; Modifier of rudimentary (Mod(r)) protein
      pfam09744
      Location:21 → 165
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:262 → 296
      RILP; Rab interacting lysosomal protein
      pfam14662
      Location:54 → 233
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl12013
      Location:152 → 277
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_171101.5 → NP_741114.2  RILP-like protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741114.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDL7
      Conserved Domains (5) summary
      pfam07200
      Location:156 → 281
      Mod_r; Modifier of rudimentary (Mod(r)) protein
      pfam09744
      Location:12 → 156
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:253 → 287
      RILP; Rab interacting lysosomal protein
      pfam14662
      Location:45 → 224
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl12013
      Location:143 → 268
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version

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