epi-1 Laminin-like protein epi-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: epi-1
Official Full Name: Laminin-like protein epi-1
Primary source: WormBase:WBGene00001328
Locus tag: CELE_K08C7.3
See related: AllianceGenome:WB:WBGene00001328
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be an extracellular matrix structural constituent. Involved in several processes, including basement membrane organization; generation of neurons; and response to misfolded protein. Located in basement membrane. Is expressed in several structures, including anal depressor muscle; basal lamina; body wall musculature; egg-laying apparatus; and intestine. Human ortholog(s) of this gene implicated in familial nephrotic syndrome; junctional epidermolysis bullosa; and lung small cell carcinoma. Orthologous to several human genes including LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See epi-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 16

Sequence:: Chromosome: IV; NC_003282.8 (10666823..10679291)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Laminin/EPI-1 is necessary for the assembly of fibulin-1C at mechanosensory neuron attachments.
Title: Selective assembly of fibulin-1 splice variants reveals distinct extracellular matrix networks and novel functions for perlecan/UNC-52 splice variants.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08C7.3 (e-PCR)
- UniSTS:321569

STS4-172 (e-PCR)
- UniSTS:242161

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonal defasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to misfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Laminin-like protein epi-1

NP_001023281.1

Confirmed by transcript evidence

NP_001023282.1

Confirmed by transcript evidence

NP_001255500.1

Confirmed by transcript evidence

NP_001255501.1

Confirmed by transcript evidence

NP_001294007.1

Confirmed by transcript evidence

NP_001294008.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10666823..10679291

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307078.4 → NP_001294007.1 Laminin-like protein epi-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294007.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AD21

Conserved Domains (13) summary

smart00136
Location:24 → 296

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:519 → 564

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1649 → 1773

LamB; Laminin B domain

COG0840
Location:2125 → 2358

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

COG1340
Location:2394 → 2670

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00055
Location:1405 → 1448

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3333 → 3490

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd02795
Location:855 → 988

CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily

pfam00053
Location:1497 → 1547

Laminin_EGF; Laminin EGF domain

pfam01442
Location:2269 → 2452

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam06009
Location:2569 → 2710

Laminin_II; Laminin Domain II

cl12013
Location:2269 → 2466

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl21509
Location:2490 → 2615

ApoLp-III_like; Apolipophorin-III and similar insect proteins
NM_001268571.3 → NP_001255500.1 Laminin-like protein epi-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255500.1

Status: REVIEWED

UniProtKB/TrEMBL

C1P640

Conserved Domains (10) summary

PTZ00121
Location:2289 → 2917

PTZ00121; MAEBL; Provisional

smart00136
Location:24 → 296

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:519 → 564

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1669 → 1793

LamB; Laminin B domain

COG0840
Location:2145 → 2378

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

cd00055
Location:471 → 520

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3321 → 3478

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd02795
Location:855 → 988

CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily

pfam06009
Location:2589 → 2730

Laminin_II; Laminin Domain II

pfam00053
Location:1426 → 1474

Laminin_EGF; Laminin EGF domain
NM_001268572.3 → NP_001255501.1 Laminin-like protein epi-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255501.1

Status: REVIEWED

UniProtKB/TrEMBL

C1P641

Conserved Domains (10) summary

PTZ00121
Location:2269 → 2897

PTZ00121; MAEBL; Provisional

smart00136
Location:24 → 296

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:519 → 564

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1649 → 1773

LamB; Laminin B domain

COG0840
Location:2125 → 2358

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

cd00055
Location:471 → 520

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3301 → 3458

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd02795
Location:855 → 988

CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily

pfam06009
Location:2569 → 2710

Laminin_II; Laminin Domain II

pfam00053
Location:1406 → 1454

Laminin_EGF; Laminin EGF domain
NM_001028110.5 → NP_001023281.1 Laminin-like protein epi-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023281.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EEV6

Conserved Domains (13) summary

smart00136
Location:24 → 296

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:519 → 564

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1658 → 1782

LamB; Laminin B domain

COG0840
Location:2134 → 2367

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

COG1340
Location:2403 → 2679

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00055
Location:1414 → 1457

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3342 → 3499

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd02795
Location:855 → 988

CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily

pfam00053
Location:1506 → 1556

Laminin_EGF; Laminin EGF domain

pfam01442
Location:2278 → 2461

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam06009
Location:2578 → 2719

Laminin_II; Laminin Domain II

cl12013
Location:2278 → 2475

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl21509
Location:2499 → 2624

ApoLp-III_like; Apolipophorin-III and similar insect proteins
NM_001028111.5 → NP_001023282.1 Laminin-like protein epi-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023282.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21313

Conserved Domains (13) summary

smart00136
Location:24 → 296

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:519 → 564

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1658 → 1782

LamB; Laminin B domain

COG0840
Location:2134 → 2367

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

COG1340
Location:2403 → 2679

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00055
Location:1414 → 1457

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3310 → 3467

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd02795
Location:855 → 988

CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily

pfam00053
Location:1506 → 1556

Laminin_EGF; Laminin EGF domain

pfam01442
Location:2278 → 2461

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam06009
Location:2578 → 2719

Laminin_II; Laminin Domain II

cl12013
Location:2278 → 2475

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl21509
Location:2499 → 2624

ApoLp-III_like; Apolipophorin-III and similar insect proteins
NM_001307079.3 → NP_001294008.1 Laminin-like protein epi-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294008.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AJI9

Conserved Domains (13) summary

smart00136
Location:24 → 296

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:519 → 564

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1669 → 1793

LamB; Laminin B domain

COG0840
Location:2145 → 2378

Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]

COG1340
Location:2414 → 2690

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00055
Location:1425 → 1468

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3353 → 3510

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd02795
Location:855 → 988

CBM6-CBM35-CBM36_like; Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily

pfam00053
Location:1517 → 1567

Laminin_EGF; Laminin EGF domain

pfam01442
Location:2289 → 2472

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam06009
Location:2589 → 2730

Laminin_II; Laminin Domain II

cl12013
Location:2289 → 2486

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl21509
Location:2510 → 2635

ApoLp-III_like; Apolipophorin-III and similar insect proteins