gmpr-1 GMP reductase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gmpr-1
Official Full Name: GMP reductase
Primary source: WormBase:WBGene00017984
Locus tag: CELE_F32D1.5
See related: AllianceGenome:WB:WBGene00017984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GMP reductase activity and metal ion binding activity. Predicted to be involved in purine nucleobase metabolic process and purine nucleotide metabolic process. Predicted to be part of GMP reductase complex. Orthologous to several human genes including GMPR (guanosine monophosphate reductase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gmpr-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (4369353..4371383, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32D1.5 (e-PCR)
- UniSTS:312578

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GMP reductase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GMP reductase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GMP reductase

NP_001317809.1

Confirmed by transcript evidence

NP_504202.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4369353..4371383 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071801.9 → NP_504202.1 GMP reductase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504202.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16294

Conserved Domains (2) summary

TIGR01305
Location:3 → 345

GMP_reduct_1; guanosine monophosphate reductase, eukaryotic

cd00381
Location:10 → 337

IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
NM_001330859.3 → NP_001317809.1 GMP reductase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A168H4W1

Conserved Domains (1) summary

TIGR01305
Location:1 → 76

GMP_reduct_1; guanosine monophosphate reductase, eukaryotic