pxl-1 Paxillin homolog 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pxl-1
Official Full Name: Paxillin homolog 1
Primary source: WormBase:WBGene00016197
Locus tag: CELE_C28H8.6
See related: AllianceGenome:WB:WBGene00016197
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables vinculin binding activity. Involved in muscle structure development; nematode larval development; and nematode pharyngeal pumping. Located in adherens junction; contractile muscle fiber; and podosome. Is expressed in body wall musculature and pharynx. Orthologous to several human genes including LPXN (leupaxin) and PXN (paxillin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pxl-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (5889721..5896013, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a loss-of-function allele of pxl-1 shows that loss of paxillin leads to early larval arrested animals with paralyzed pharyngeal muscles and eventual lethality
Title: The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C28H8.6 (e-PCR)
- UniSTS:319078

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vinculin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle structure development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IEA Inferred from Electronic Annotation more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed
located_in podosome	IEA Inferred from Electronic Annotation more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Paxillin homolog 1

NP_001021185.2

Confirmed by transcript evidence

NP_001021186.1

Confirmed by transcript evidence

NP_001122677.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5889721..5896013 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026015.3 → NP_001021186.1 Paxillin homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021186.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09476

Conserved Domains (2) summary

pfam00412
Location:148 → 203

LIM; LIM domain

cl02475
Location:87 → 141

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001129205.4 → NP_001122677.1 Paxillin homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122677.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09476

Conserved Domains (4) summary

cd09338
Location:233 → 285

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09339
Location:292 → 343

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family

pfam00412
Location:174 → 229

LIM; LIM domain

cl02475
Location:113 → 167

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001026014.5 → NP_001021185.2 Paxillin homolog 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021185.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A7YEM2, A7YEP3, A8WEL3, Q09476, Q6AHR2

Conserved Domains (4) summary

cd09338
Location:294 → 346

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09339
Location:353 → 404

LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family

cd09406
Location:174 → 228

LIM1_Leupaxin; The first LIM domain of Leupaxin

pfam00412
Location:235 → 290

LIM; LIM domain