spo-11 DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spo-11
Official Full Name: DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11
Primary source: WormBase:WBGene00004985
Locus tag: CELE_T05E11.4
See related: AllianceGenome:WB:WBGene00004985
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity. Involved in meiotic DNA double-strand break processing. Predicted to be located in chromosome and nucleus. Predicted to be active in nuclear chromosome. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See spo-11 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (11123133..11124862, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our studies highlight previously unknown functions of CRL4 in C. elegans meiosis and show that CUL-4 likely plays multiple roles in meiosis that are essential for maintaining genome integrity.
Title: CRL4 regulates recombination and synaptonemal complex aggregation in the Caenorhabditis elegans germline.
Data indicate that SPO-11 is monomeric and binds DNA, double-stranded DNA in particular.
Title: Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T05E11.4 (e-PCR)
- UniSTS:307928

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase activity	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in meiotic DNA double-strand break formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA double-strand break formation	IEA Inferred from Electronic Annotation more info
involved_in meiotic DNA double-strand break processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA double-strand break processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive process	IEA Inferred from Electronic Annotation more info
involved_in sexual reproduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11

NP_001294010.1

Confirmed by transcript evidence

NP_502081.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11123133..11124862 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069680.5 → NP_502081.1 Meiotic recombination protein spo-11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502081.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22236

Conserved Domains (2) summary

cd00223
Location:196 → 358

TOPRIM_TopoIIB_SPO; TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) ...

pfam04406
Location:91 → 151

TP6A_N; Type IIB DNA topoisomerase
NM_001307081.3 → NP_001294010.1 DNA topoisomerase (ATP-hydrolyzing) [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294010.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A061AD57

Conserved Domains (2) summary

cd00223
Location:149 → 311

TOPRIM_TopoIIB_SPO; topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces ...

pfam04406
Location:45 → 103

TP6A_N; Type IIB DNA topoisomerase