dyn-1 Dynamin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dyn-1
Official Full Name: Dynamin
Primary source: WormBase:WBGene00001130
Locus tag: CELE_C02C6.1
See related: AllianceGenome:WB:WBGene00001130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activity. Involved in several processes, including embryo development; endocytosis; and necroptotic process. Located in several cellular components, including cleavage furrow; periciliary membrane compartment; and pseudopodium. Is expressed in several structures, including hermaphrodite gonad; hypodermis; nervous system; pharynx; and rectal valve cell. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; developmental and epileptic encephalopathy 31A; developmental and epileptic encephalopathy 31B; and lethal congenital contracture syndrome. Orthologous to human DNM1 (dynamin 1); DNM2 (dynamin 2); and DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dyn-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (15568921..15573021)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dynamin is a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis
Title: A multiscale study of the role of dynamin in the regulation of glucose uptake.
RAB-5- and DYNAMIN-1-mediated endocytosis of EFF-1 fusogen controls cell-cell fusion.
Title: RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion.
PAR-3 and PAR-6 function in cytokinesis may be partially redundant and play a role in the maintenance of DYN-1 in the cleavage furrow.
Title: Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.
Results describe the oligomerization of dynamin-1 (DYN-1) in living C. elegans embryos and identified DYN-1 mutations that abolish DYN-1's oligomerization or GTPase activities.
Title: Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells.
The Caenorhabditis elegans dynamin ortholog, DYN-1, maintains anterior polarity cues.
Title: Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo.
In Caenorhabditis elegans, dynamin localized to newly formed cleavage furrow membranes and accumulated at the midbody of dividing embryos in a manner similar to dynamin localization in mammalian cells
Title: The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C02C6.1 (e-PCR)
- UniSTS:317264

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagosome maturation involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in periciliary membrane compartment	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Dynamin

NP_001024332.1

Confirmed by transcript evidence

NP_001359587.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15568921..15573021

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373600.5 → NP_001359587.1 Dynamin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P39055, Q93176, Q95QY9

UniProtKB/TrEMBL

Q9U9I9

Conserved Domains (4) summary

cd08771
Location:31 → 296

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

cd01256
Location:518 → 628

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:218 → 505

Dynamin_M; Dynamin central region

pfam02212
Location:650 → 739

GED; Dynamin GTPase effector domain
NM_001029161.5 → NP_001024332.1 Dynamin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024332.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U9I9

Conserved Domains (6) summary

smart00302
Location:648 → 739

GED; Dynamin GTPase effector domain

cd08771
Location:31 → 296

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:80 → 567

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:518 → 628

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam00169
Location:520 → 622

PH; PH domain

pfam01031
Location:219 → 505

Dynamin_M; Dynamin central region