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    vem-1 Protein vem-1 [ Caenorhabditis elegans ]

    Gene ID: 181066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vem-1
    Official Full Name
    Protein vem-1
    Primary source
    WormBase:WBGene00006890
    Locus tag
    CELE_K07E3.8
    See related
    AllianceGenome:WB:WBGene00006890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Located in axon. Is expressed in AVG; head neurons; and somatic nervous system. Orthologous to several human genes including PGRMC1 (progesterone receptor membrane component 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vem-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    3
    Sequence:
    Chromosome: X; NC_003284.9 (8087553..8088574, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene formate--tetrahydrofolate ligase Neighboring gene methenyltetrahydrofolate cyclohydrolase Neighboring gene Cation-transporting ATPase;Cation-transporting ATPase catp-5 Neighboring gene ncRNA Neighboring gene Non-specific serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease. Yi B, et al. J Neurochem, 2017 Feb. PMID 27926996, Free PMC Article
    2. Caenorhabditis elegans VEM-1, a novel membrane protein, regulates the guidance of ventral nerve cord-associated axons. Runko E, et al. J Neurosci, 2004 Oct 13. PMID 15483120, Free PMC Article
    3. Expression profiling of five different xenobiotics using a Caenorhabditis elegans whole genome microarray. Reichert K, et al. Chemosphere, 2005 Oct. PMID 16168746
    4. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article
    5. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein vem-1
    NP_001024770.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8087553..8088574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029599.11 → NP_001024770.1  Protein vem-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YZW5
      Conserved Domains (1) summary
      pfam00173
      Location:51 → 106
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YZW5.1

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