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    frg-1 Protein FRG1 homolog [ Caenorhabditis elegans ]

    Gene ID: 176719, updated on 9-Dec-2024

    Summary

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    Official Symbol
    frg-1
    Official Full Name
    Protein FRG1 homolog
    Primary source
    WormBase:WBGene00014177
    Locus tag
    CELE_ZK1010.3
    See related
    AllianceGenome:WB:WBGene00014177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables actin filament binding activity and protein homodimerization activity. Involved in actin filament bundle assembly. Located in nucleolus and striated muscle dense body. Used to study facioscapulohumeral muscular dystrophy. Orthologous to human FRG1 (FSHD region gene 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See frg-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (12979162..12980163)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF155 domain-containing protein Neighboring gene Ubiquitin Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA Neighboring gene Proteoglycan 4-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Facioscapulohumeral muscular dystrophy region gene-1 (FRG-1) is an actin-bundling protein associated with muscle-attachment sites. Liu Q, et al. J Cell Sci, 2010 Apr 1. PMID 20215405, Free PMC Article
    2. FRG1, a gene in the FSH muscular dystrophy region on human chromosome 4q35, is highly conserved in vertebrates and invertebrates. Grewal PK, et al. Gene, 1998 Aug 17. PMID 9714712
    3. C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments. Liu Q, et al. Cell Biosci, 2012 May 22. PMID 22616817, Free PMC Article
    4. Bending amplitude - a new quantitative assay of C. elegans locomotion: identification of phenotypes for mutants in genes encoding muscle focal adhesion components. Nahabedian JF, et al. Methods, 2012 Jan. PMID 22126736, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in striated muscle dense body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein FRG1 homolog
    NP_499696.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12979162..12980163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067295.8 → NP_499696.2  Protein FRG1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499696.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18282
      Conserved Domains (1) summary
      pfam06229
      Location:78 → 273
      FRG1; FRG1-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18282.2

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