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    sbds-1 Ribosome maturation protein SBDS [ Caenorhabditis elegans ]

    Gene ID: 175218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sbds-1
    Official Full Name
    Ribosome maturation protein SBDS
    Primary source
    WormBase:WBGene00021063
    Locus tag
    CELE_W06E11.4
    See related
    AllianceGenome:WB:WBGene00021063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cytosolic ribosome assembly. Predicted to be located in cytoplasm; nuclear lumen; and spindle. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome and aplastic anemia. Orthologous to human SBDS (SBDS ribosome maturation factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sbds-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (636486..638419, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein phosphatase fem-2 Neighboring gene Uncharacterized protein Neighboring gene Golgin subfamily A member 7/ERF4 domain-containing protein Neighboring gene Major sperm protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in SBDS are associated with Shwachman-Diamond syndrome. Boocock GR, et al. Nat Genet, 2003 Jan. PMID 12496757
    2. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cytosolic ribosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ribosome maturation protein SBDS
    NP_497226.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      636486..638419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064825.8 → NP_497226.2  Ribosome maturation protein SBDS [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497226.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23202
      Conserved Domains (3) summary
      COG1500
      Location:11 → 244
      Sdo1; Ribosome maturation protein Sdo1 [Translation, ribosomal structure and biogenesis]
      pfam01172
      Location:19 → 100
      SBDS; Shwachman-Bodian-Diamond syndrome (SBDS) protein
      pfam09377
      Location:111 → 227
      SBDS_C; SBDS protein C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23202.2

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