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    cdk-14 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171672, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdk-14
    Official Full Name
    Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00022519
    Locus tag
    CELE_ZC123.4
    See related
    AllianceGenome:WB:WBGene00022519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Predicted to be active in cytosol and nucleus. Orthologous to human CDK14 (cyclin dependent kinase 14) and CDK15 (cyclin dependent kinase 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdk-14 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (841742..846763, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Zinc Finger and Homeobox;Zinc finger homeobox protein 4;Zinc finger protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sperm mitochondrial-associated cysteine-rich protein-like Neighboring gene ncRNA Neighboring gene DZF domain-containing protein Neighboring gene Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-6 Neighboring gene Bursicon;Bursicon subunit alpha;Secreted protein Neighboring gene FBD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner. Hisamoto N, et al. J Neurosci, 2021 Oct 6. PMID 34429379, Free PMC Article
    2. Gamma radiation induces life stage-dependent reprotoxicity in Caenorhabditis elegans via impairment of spermatogenesis. Maremonti E, et al. Sci Total Environ, 2019 Dec 10. PMID 31425988
    3. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner.
      Title: CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein
    NP_001382289.1
    • Confirmed by transcript evidence
    NP_001382290.1
    • Confirmed by transcript evidence
    NP_490783.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      841742..846763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058382.5 → NP_490783.3  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490783.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0S6
      Conserved Domains (1) summary
      cl21453
      Location:216 → 506
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001395341.1 → NP_001382289.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0S7
      Conserved Domains (1) summary
      cl21453
      Location:132 → 422
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001395342.1 → NP_001382290.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q65CM2
      Conserved Domains (1) summary
      cl21453
      Location:60 → 350
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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