mau-8 Phosducin domain-containing protein;Phosducin thioredoxin-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mau-8
Official Full Name: Phosducin domain-containing protein;Phosducin thioredoxin-like domain-containing protein
Primary source: WormBase:WBGene00003142
Locus tag: CELE_Y62E10A.8
See related: AllianceGenome:WB:WBGene00003142
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Is expressed in body wall musculature; germ line; hypodermis; intestine; and pharynx. Orthologous to human PDC (phosducin) and PDCL (phosducin like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mau-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (13378016..13380459)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAU-8/PhLP modulates G protein signaling, stability and subcellular location to regulate various physiological functions, and MAU-8 might not be limited to the Galphaq/Galphao network
Title: MAU-8 is a Phosducin-like Protein required for G protein signaling in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y62E10A.g (e-PCR)
- UniSTS:324458

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: Phosducin domain-containing protein;Phosducin thioredoxin-like domain-containing protein

NP_001255734.1

Partially confirmed by transcript evidence

NP_001367275.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13378016..13380459

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268805.4 → NP_001255734.1 Phosducin thioredoxin-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255734.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1X7

Conserved Domains (1) summary

cd02987
Location:43 → 238

Phd_like_Phd; Phosducin (Phd)-like family, Phd subfamily; Phd is a cytosolic regulator of G protein functions. It specifically binds G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane. This impedes ...
NM_001380514.1 → NP_001367275.1 Phosducin domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

E6N0W2