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    mpk-2 Mitogen-activated protein kinase [ Caenorhabditis elegans ]

    Gene ID: 173880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mpk-2
    Official Full Name
    Mitogen-activated protein kinase
    Primary source
    WormBase:WBGene00003402
    Locus tag
    CELE_C04G6.1
    See related
    AllianceGenome:WB:WBGene00003402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mpk-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    13
    Sequence:
    Chromosome: II; NC_003280.10 (5104118..5108901)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Intrinsically Disordered Protein, class B Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Mitogen-activated protein kinase Neighboring gene Protein UBASH3A homolog Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of Caenohabditis elegans MAPK Signaling Pathways in Oxidative Stress Response Induced by Silver Nanoparticles Exposure. Roh JY, et al. Toxicol Res, 2012 Mar. PMID 24278585, Free PMC Article
    2. MAP kinase function in C. elegans. Selfors LM, et al. Bioessays, 1994 May. PMID 8024537
    3. A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Lackner MR, et al. Genes Dev, 1994 Jan. PMID 8299936
    4. Signal transduction and cell fate specification during Caenorhabditis elegans vulval development. Eisenmann DM, et al. Curr Opin Genet Dev, 1994 Aug. PMID 7950317
    5. KSR: a novel player in the RAS pathway. Downward J. Cell, 1995 Dec 15. PMID 8521506

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mitogen-activated protein kinase
    NP_001021913.1
    • Confirmed by transcript evidence
    NP_494946.2
    • Partially confirmed by transcript evidence
    NP_494947.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5104118..5108901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026742.5 → NP_001021913.1  Mitogen-activated protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6ABN8
      Conserved Domains (2) summary
      smart00220
      Location:22 → 317
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:19 → 341
      PKc_like; Protein Kinases, catalytic domain

    2. NM_062546.8 → NP_494947.2  Mitogen-activated protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494947.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG56
      Conserved Domains (2) summary
      smart00220
      Location:57 → 352
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07834
      Location:57 → 398
      STKc_MAPK; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase

    3. NM_062545.9 → NP_494946.2  Mitogen-activated protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494946.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYF8
      Conserved Domains (2) summary
      smart00220
      Location:57 → 352
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:54 → 376
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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