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    timp-1 NTR domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179199, updated on 9-Dec-2024

    Summary

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    Official Symbol
    timp-1
    Official Full Name
    NTR domain-containing protein
    Primary source
    WormBase:WBGene00019476
    Locus tag
    CELE_K07C11.3
    See related
    AllianceGenome:WB:WBGene00019476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase inhibitor activity. Predicted to be involved in negative regulation of membrane protein ectodomain proteolysis. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including coelomocyte; gonad; hypodermis; nerve ring; and vulval cell. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See timp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (8207235..8207997)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Putative metalloproteinase inhibitor tag-225 Neighboring gene Carboxylic ester hydrolase Neighboring gene ncRNA Neighboring gene Calcineurin-like phosphoesterase domain-containing protein;UPF0046 protein K07C11.7 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Conserved oligomeric Golgi complex subunit 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Role of Tissue Inhibitors of Metalloproteinases in Organ Development and Regulation of ADAMTS Family Metalloproteinases in Caenorhabditis elegans. Kubota Y, et al. Genetics, 2019 Jun. PMID 30992386, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both TIMP-1 and CRI-2 act as inhibitors of MIG-17 and GON-1 ADAMTSs to regulate gonad development in a noncell-autonomous manner.
      Title: The Role of Tissue Inhibitors of Metalloproteinases in Organ Development and Regulation of ADAMTS Family Metalloproteinases in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NTR domain-containing protein
    NP_505115.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8207235..8207997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072714.8 → NP_505115.1  NTR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505115.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21267
      Conserved Domains (1) summary
      cd03577
      Location:21 → 138
      NTR_TIMP_like; NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
    Nucleotide Protein
    Heading Accession and Version

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