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    nog-1 Nucleolar GTP-binding protein 1 [ Caenorhabditis elegans ]

    Gene ID: 176863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nog-1
    Official Full Name
    Nucleolar GTP-binding protein 1
    Primary source
    WormBase:WBGene00020297
    Locus tag
    CELE_T07A9.9
    See related
    AllianceGenome:WB:WBGene00020297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity and RNA binding activity. Involved in determination of adult lifespan; negative regulation of lipid storage; and regulation of reproductive process. Located in nucleolus. Is expressed in several structures, including excretory cell; germ cell; intestine; pharynx; and vulva. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nog-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (393880..396420)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sjogren's Syndrome Nuclear Autoantigen Neighboring gene Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial Neighboring gene Syntaxin-binding protein 1 Neighboring gene Cytochrome c oxidase assembly protein COX14 Neighboring gene Ribosomal RNA-processing protein 8 Neighboring gene Guanine nucleotide-binding protein alpha-4 subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA. Zhu C, et al. Proc Natl Acad Sci U S A, 2018 Oct 2. PMID 30224484, Free PMC Article
    2. Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans. Kim YI, et al. Mol Cells, 2014 Jan. PMID 24552710, Free PMC Article
    3. rRNA intermediates coordinate the formation of nucleolar vacuoles in C. elegans. Xu D, et al. Cell Rep, 2023 Aug 29. PMID 37537842
    4. Sperm chromatin proteomics identifies evolutionarily conserved fertility factors. Chu DS, et al. Nature, 2006 Sep 7. PMID 16943775, Free PMC Article
    5. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nog-1 in C. elegans may be an important player in regulating life span and fat storage via the insulin/IGF pathway.
      Title: Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipid storage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleolar GTP-binding protein 1
    NP_741288.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      393880..396420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171242.6 → NP_741288.1  Nucleolar GTP-binding protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44411, Q8MXI6
      Conserved Domains (3) summary
      cd01897
      Location:170 → 341
      NOG; Nucleolar GTP-binding protein (NOG)
      COG1084
      Location:3 → 346
      Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
      pfam08155
      Location:445 → 495
      NOGCT; NOGCT (NUC087) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44411.1

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